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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK4
All Species:
16.67
Human Site:
S505
Identified Species:
28.21
UniProt:
Q9NR20
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR20
NP_003836.1
520
59608
S505
S
M
T
S
P
G
Q
S
K
N
F
S
L
K
N
Chimpanzee
Pan troglodytes
XP_001158495
520
59654
S505
S
M
T
S
P
G
Q
S
K
N
L
S
L
K
N
Rhesus Macaque
Macaca mulatta
XP_001101112
520
59434
S505
S
T
T
S
P
G
Q
S
K
N
F
S
L
K
N
Dog
Lupus familis
XP_534917
565
65190
Q549
S
K
T
S
P
G
K
Q
S
K
N
S
S
P
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8BI55
632
72542
Q616
G
S
E
M
S
A
E
Q
Q
S
T
S
S
P
K
Rat
Rattus norvegicus
Q4V8A3
586
65492
S561
P
P
V
V
G
I
A
S
K
L
K
A
N
L
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509988
466
52101
M452
L
S
S
V
V
K
G
M
A
W
I
T
G
S
S
Chicken
Gallus gallus
Q5ZIU3
526
59419
D510
T
N
L
A
Q
M
T
D
A
N
G
N
I
Q
Q
Frog
Xenopus laevis
Q2TAE3
750
84138
T643
G
N
S
H
H
S
M
T
S
L
S
S
S
T
T
Zebra Danio
Brachydanio rerio
XP_693389
634
72240
T613
Q
I
I
I
K
P
Q
T
G
S
S
S
D
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V3D5
722
79590
S599
M
Q
K
V
A
V
R
S
K
I
T
S
S
V
S
Honey Bee
Apis mellifera
XP_396369
614
68978
S581
S
S
H
A
L
A
S
S
T
Q
T
T
T
S
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51568
400
46206
T386
Y
D
P
S
E
R
L
T
A
N
E
A
L
D
H
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
I770
D
S
V
D
I
G
A
I
S
K
R
K
E
N
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.8
89.2
76.9
N.A.
65.3
38.7
N.A.
54.2
43.1
28
48.9
N.A.
37.5
42.3
N.A.
N.A.
Protein Similarity:
100
99
91.5
81.2
N.A.
71.5
53.9
N.A.
66.1
59.7
43.3
61.8
N.A.
50.1
59.1
N.A.
N.A.
P-Site Identity:
100
93.3
93.3
40
N.A.
6.6
13.3
N.A.
0
6.6
6.6
13.3
N.A.
20
13.3
N.A.
N.A.
P-Site Similarity:
100
93.3
93.3
46.6
N.A.
26.6
20
N.A.
20
40
20
40
N.A.
33.3
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.8
22.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
42.5
36.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
15
8
15
15
0
22
0
0
15
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
0
8
0
0
0
8
0
0
0
0
8
8
0
% D
% Glu:
0
0
8
0
8
0
8
0
0
0
8
0
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
15
0
0
0
0
% F
% Gly:
15
0
0
0
8
36
8
0
8
0
8
0
8
0
0
% G
% His:
0
0
8
8
8
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
8
8
8
8
8
0
8
0
8
8
0
8
0
0
% I
% Lys:
0
8
8
0
8
8
8
0
36
15
8
8
0
22
15
% K
% Leu:
8
0
8
0
8
0
8
0
0
15
8
0
29
8
0
% L
% Met:
8
15
0
8
0
8
8
8
0
0
0
0
0
0
8
% M
% Asn:
0
15
0
0
0
0
0
0
0
36
8
8
8
8
22
% N
% Pro:
8
8
8
0
29
8
0
0
0
0
0
0
0
15
0
% P
% Gln:
8
8
0
0
8
0
29
15
8
8
0
0
0
8
8
% Q
% Arg:
0
0
0
0
0
8
8
0
0
0
8
0
0
0
8
% R
% Ser:
36
29
15
36
8
8
8
43
22
15
15
58
29
22
22
% S
% Thr:
8
8
29
0
0
0
8
22
8
0
22
15
8
8
15
% T
% Val:
0
0
15
22
8
8
0
0
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _